Efecto antidiabético y neuroprotector de Tectona grandis Linn. En la diabetes inducida Aloxana

Abstract

In the present study, effect of ethanolic extract of bark of Tectona grandis Linn. (TG) was evaluatedusing alloxan induced diabetes and associated renal complication. The diabetes was induced byadministration of alloxan to the rats at the dose of 140 mg/kg, i.p. TG was administered to diabeticanimals for six weeks and various biochemical parameters in blood and urine (plasma glucose, serumalbumin, total protein, and creatinine, urine total protein, urine albumin), tissue parameters(cholesterol and triglyceride in kidney homogenate) and % change in body weight were evaluatedalong with histopathological study. In present study diabetic animals treated with TG showedsignificant reduction in the elevated level of plasma glucose (p<0.01) when compared with diabeticcontrol. While considering renal parameters, diabetic animals treated with TG showed significantdecrease in serum creatinine (p<0.05), urine albumin and urine total protein levels (p<0.01) andsignificant increase in serum albumin, total protein and % change in body weight (p<0.01) whencompared with diabetic control. Diabetic control showed significant increase in total cholesterol andtriglyceride accumulation in kidney, while diabetic animals treated with TG showed significantdecrease in levels of total cholesterol (p<0.01) and triglyceride (p<0.05) in the kidney when comparedwith diabetic control. Diabetic control showed significant mark of glomerulosclerosis andhyalinization which occurs because of severe diabetic condition (diabetic nephropathy). Diabeticgroups treated with TG showed absence of the sclerotic lesions produced by diabetic condition. Hence,the results obtained in the present study indicate that Tectona grandis has the potential to treat diabetesmellitus and prevent the associated renal damage.