Abstract
The aim of this study was conducted to evaluate the effect of Gundelia tournefortii on some biochemical parameters in hyperglycemic and hyperlipidemic mice. Male albino mice were induced hyperglycemic and hyperlipidemic by daily injection of dexamethasone 1 mg/kg of body weight intramuscularly (i.m.), the mice randomly divided into five groups (6-8 mice in each group). The group 1: served as negative control group; the group 2: injected with dexamethasone at dose 1 mg /kg.b.w.i.m and served as positive control group; the groups 3, 4, 5: treated with extract of G. tournefortii at doses: 75, 150, 300 mg/kg.b.w. orally respectively companied with injection of dexamethasone 1 mg/kg.b.w.i.m. All treatment were once daily for 22 days. Dexamethasone treatment lead to significant increase in levels of glucose, cholesterol, and triglyceride, and significant decrease of body weight, without any effect on level of total protein. G. tournefortii extract treatment at doses: 75 mg/kg.b.w. resulted significant decrease levels of glucose, and body weight. Beneficial effect were seen when mice treated with G. tournefortii at dose of 300 mg/kg.b.w. that lead to significant decrease in levels of glucose, triglyceride, and cholesterol. These results indicate the usefulness of G. tournefortii extract as hypoglycemia and hypolipidemia in dexamethasone treated mice.
Highlights
Plant extractBoiled water extract was prepared by weighing and Diabetes mellitus is a metabolic disorder characterized cutting up a certain weight of plant roots into small pieces, by resistance to the action of insulin, insufficient secretion, plant pieces were put in conical flask and submerged by or both [1]
1cm of distilled water, the mixture heated in shaking water bath at 95C◦ for 30 minutes [19].The mixture was filtrated insulin resistance are associated with disturbance in though a piece of cotton and several layers of gauze which lipid and protein metabolism [2]
As shown from table 1 the results reflect the effect of dexamethasone treating alone or in combination with different doses of G. tournefortii extract on the body weight in mice, the results show that dexamethasone causes a significant decrease in body weight after 22 days when compared with zero time in the same group, dexamethasone combination with G. tournefortii extract causes significant decrease in body weight in dose 75 mg/kg.b.w. when compare with dexamethasone treated group, and the doses 150 and 300 mg /kg.b.w lead to significant decrease in body weight when compared with zero time in same groups
Summary
Boiled water extract was prepared by weighing and Diabetes mellitus is a metabolic disorder characterized cutting up a certain weight of plant roots into small pieces, by resistance to the action of insulin, insufficient secretion, plant pieces were put in conical flask and submerged by or both [1]. The major clinical manifestation of the diabetes state is hyperglycemia, insulin deficiency and/or. WHO indicates that put on the funnel mouth and left for 24 hr to complete the diabetes mellitus is one of the major killers of humans in filtration process and the filtrate stored in dark bottles in the our time [3].
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