Abstract
<p><em>Elderly patients need special and thorough attention, because in elderly patients often occur more than one disease multipatologi. One of them is an infectious disease that is prone to occur in elderly patients due to decreased functional body reserve, decreased immunity, repeated hospital stays, diagnosis and therapy that is often late, decreased response to antibiotic therapy, and increased potential for side effects and interactions between drug. Fungal infections are an increasing problem in the elderly population including opportunistic fungal infections in elderly patients with immunocompromised conditions with multipatolgi disease and coincidence, post chemotherapy in malignancies, post-transplantation, or receive immunosuppressant therapy due to dermatological and rheumatological diseases.</em><strong><em></em></strong></p>
Highlights
Penduduk lanjut usia atau geriatri di seluruh dunia diproyeksikan tumbuh dengan sangat cepat, bahkan tercepat dibanding kelompok usia lainnya
because in elderly patients often occur more than one disease multipatologi
prone to occur in elderly patients
Summary
Penduduk lanjut usia atau geriatri di seluruh dunia diproyeksikan tumbuh dengan sangat cepat, bahkan tercepat dibanding kelompok usia lainnya. Salah satunya yaitu penyakit infeksi yang rentan terjadi pada pasien usia lanjut karena penurunan cadangan fungsional tubuh, penurunan imunitas, rawat inap di RS yang berulang kali, diagnosis dan terapi yang sering terlambat, penurunan respon terhadap terapi antibiotik, dan meningkatnya potensi efek samping serta interaksi antar-obat. Gangguan kemampuan untuk meningkatkan respons imun terhadap antigen baru dapat mengakibatkan kerentanan terhadap penyakit menular.[15] Respons imun terhadap antigen bergantung pada sel T naif.[15] Imunodefisiensi dan involusi timus yang berkaitan dengan usia akan mengakibatkan openurunan sel T CD8 + naïf, situasi ini membuat tubuh praktis kekurangan sel T naïf yangyang mengakibatkan tubuh lebih rentan terhadap berbagai infeksi dan penyakit menular ataupun penyakit tidak menular.[15]
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