Abstract

There are two main strategies for the induction of transcription: a strong promoter is negatively controlled by a repressor protein and induction of transcription is effected by an inducer (a ligand that inactivates the repressor). Alternatively, a weak promoter is positively controlled by an activator protein bound to a coactivator (a ligand required for transcription activation). The lac operon, one of the paradigms of transcription regulation, is subject to both negative and positive control. A closer look at this system reveals that, while the principle of transcription induction seems simple, actual inducible biological systems tend to be complex.

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