Abstract
During the 2022 winter, Europe experienced a surge in invasive group A streptococcal (iGAS) infections in paediatric patients, accompanied by reports of severe complications such as cerebral venous sinus thrombosis (CVST). This study retrospectively analysed the cases of four patients with CVST secondary to otogenic infections due to Streptococcus pyogenes, who were admitted between November 2022 and March 2023 at the Bologna Ospedale Maggiore. All patients presented with sepsis signs and otogenic symptoms, with imaging confirming CVST. Treatment included broad-spectrum antibiotics, anticoagulation and surgical interventions, which led to full recovery. The findings highlight the need for early recognition, timely imaging and appropriate management in severe iGAS cases.
Published Version
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