Abstract
The epileptic activity was induced by an injection of cobalt chloride solution into the unilateral sensorimotor cortex of rats. Cyclic AMP accumulations elicited by adenosine and 2-chloroadenosine were investigated in slices from different regions of the epileptic cortex. The cyclic AMP accumulation was increased in the primary cortical region of cobalt-induced epilepsy. The greatest increase in cyclic AMP accumulation was detected between 2 and 3 weeks after treatment by cobalt, in conjunction with the electrographic and behavioral findings. The results suggest the functional significance of cortical cyclic AMP-generating systems in cobalt-induced epilepsy.
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