Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry

Abstract

AimsTo determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. MethodsOur study is based on diabetes manifestation data of the 0.5–<18-year-old children/adolescents from the German multicenter Diabetes Prospective Follow-up Registry. Based on long-term pre-pandemic trends from 2011 to 2019, we estimated adjusted incidence rate ratios (IRR) for T1D and DKA, and prevalence rate ratios (PRR) regarding autoantibody status with 95 % confidence intervals (CI) for the years 2020 and 2021 (observed versus predicted rates), using multivariable negative binomial or beta-binomial regression, respectively. ResultsWe analyzed data of 30,840 children and adolescents with new-onset T1D. The observed incidences were significantly higher than the predicted incidences (IRR2020 1.13 [1.08–1.19]; IRR2021 1.20 [1.15–1.26]). The prevalence of autoantibody-negative diabetes did not change (PRR2020 0.91 [0.75–1.10]; PRR2021 1.03 [0.86–1.24]). The incidence of DKA during the pandemic was higher than predicted (IRR2020 1.34 [1.23–1.46]; IRR2021 1.37 [1.26–1.49]). ConclusionsAn increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary.