Abstract
Food allergy and atopy can be manifestations of monogenic inborn errors of immunity (IEI), a group of genetic conditions affecting immune system development and/or function. Single gene disorders provide a unique opportunity to examine the pathophysiology of food allergy and can inform the development of targeted treatments. IEIs with associated type 2 inflammation can be categorized based on pathophysiologic underpinnings of atopy development, which broadly relate to skin barrier and immune system function. When atopic patients display clinical or laboratory “red flags,” further evaluation for underlying monogenic disorders is essential.
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