Abstract
Objective. The aim of study was to determine the in vivo antioxidant activity of newly formulated O/W cream of methanolic extract of Cassia tora L. leaves. Methods. Oil in water (O/W) creams (0.05%, 0.1%, and 0.2%), cream base, methanolic extract of C. tora L. leaves (CTM), and standard (0.05% tretinoin cream) were screened for in vivo antioxidant activity. The ultraviolet- (UV-) B-induced rats were treated with different standard, O/W creams, cream base, and methanolic extract of Cassia tora L. leaves (CTM). The parameters like lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels were assessed. Results. The result of acute dermal toxicity shows that the creams were safe up to 2000 mg/kg (topically). Exposure of ultraviolet light of medium wave (UV-B light) decreased the level of GSH, CAT, and SOD and increased the LPO level. Concluding Remarks. We conclude that topical O/W creams of C. tora L. prevent the oxidative stress induced in rats by exposure to UV-B light by virtue of its in vivo antioxidant property, and these findings help to understand the mechanism of the antipsoriatic activity of O/W creams of C. tora L. in UV-B-induced psoriasis in the rat.
Highlights
Oxidative stress resulting from acute exercise in unadapted and adapted subjects has been proposed to damage enzymes, protein receptors, lipid membranes, and DNA [1]. e plant C. tora L. (Caesalpiniaceae) is traditionally claimed to be useful in the treatment of psoriasis and other skin diseases [2, 3]
C. tora L. leaves enriched in glycosides and containing aloe-emodin may be bene cial for the skin diseases [4]
It was proposed to evaluate the efficacy of Oil in water (O/W) creams and methanolic extract of C. tora L. leaves (CTM) to prevent the UV-B-induced oxidative stress
Summary
Oxidative stress resulting from acute exercise in unadapted and adapted subjects has been proposed to damage enzymes, protein receptors, lipid membranes, and DNA [1]. C. tora L. leaves enriched in glycosides and containing aloe-emodin may be bene cial for the skin diseases [4]. C. tora L. has been reported to possess a signi cant antioxidant activity in in vitro activity by using DPPH (2,2 -diphenyl-1-picryhydrazyl) method [5]. It was proposed to evaluate the efficacy of O/W creams and methanolic extract of C. tora L. leaves (CTM) to prevent the UV-B-induced oxidative stress
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