Abstract
The Hyptis genus has more than 400 species, many of them being used in folk medicine to treat several conditions. Some anticancer compounds have been isolated from plants of this genus, and for that reason we decided to investigate the potential in vivo antitumor activity of extracts of leaves of Hyptis mutabilis with different polarities (hexane, methanol, water, and hot water) against two mice tumors: sarcoma 180 and Ehrlich solid tumor. Phytochemical analysis revealed strong presence of steroids, saponins, flavonoids (mainly dihydroflavanols), and catechins. Acute toxicity was perfomed according to the up-and-down method showing LD50 values ranging from 100 up to 2500 mg/kg. Antitumor activity was investigated using 10% of the LD50 for each extract. Methotrexate was used as positive control. Both aqueous extracts showed strong inhibition of tumor growth with values up to 70% of inhibition growth for sarcoma 180. Ehrlich solid tumor was only slight inhibited by hexane extract (38.6%). In conclusion, the aqueous extracts of H. mutabilis showed promising results against sarcoma 180 mice tumor.
Highlights
E genus Hyptis (Lamiaceae) has more than 400 species distributed in tropical regions of Americas and Africa [1,2,3]
E Hyptis genus has more than 400 species, many of them being used in folk medicine to treat several conditions
Some anticancer compounds have been isolated from plants of this genus, and for that reason we decided to investigate the potential in vivo antitumor activity of extracts of leaves of Hyptis mutabilis with different polarities against two mice tumors: sarcoma 180 and Ehrlich solid tumor
Summary
E genus Hyptis (Lamiaceae) has more than 400 species distributed in tropical regions of Americas and Africa [1,2,3]. Several species of this genus are aromatic and used in folk medicine to treat digestives disorders, pain, gastrointestinal problems, and skin infections [4]. E anticancer agents 3 -demethyldesoxypodophyllotoxin and betulinic acid were isolated from plants of this genus [13]. Based on these ndings, we evaluated the antitumor activity of Hyptis mutabilis
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have