Abstract
The angiogenic activity ofAloe vera (Aloe barbadensis), known as a good healing plant, was investigated. We have extracted and fractionated dichloromethane extract (G1M1D1) and methanol soluble fraction of dichloromethane extract (G1M1D1M1) which contain low-molecular weight substances ofAloe vera gel. G1M1D1 and G1M1D1M1 fractions induced a radially arranged, spoke-wheel-like vasculature in chick embryo chorioallantoic membrane (CAM) assay. The angiogenic activity was dose-dependent and the angiogenic pattern in the CAM assay was very similar to that of phorbol 12-myristate-13-acetate (PMA) used as a positive contol. The modified CAM assay, a simple and accurate quantitating method, was used to quantitate the angiogenic activity of G1M1D1M1 fraction. Application of G1M1D1M1 fraction (100 μg/egg) resulted in much more intense angiogenesis than in contol while slightly less intense angiogenesis than in PMA (100 ng/egg).
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