Abstract
Summary Foam cells obtained from rabbit atherosclerotic lesions were incubated in vitro with [ 14 C]sodium oleate: the uptake of the fatty acid and its subsequent incorporation into other lipid fractions was determined. Most of the fatty acid taken up by the cells was incorporated into phospholipid (predominantly phosphatidylcholine) and into cholesterol ester with lesser amounts into triglyceride. The specific activity of the phospholipid-oleic acid was greater than that of the cholesterol ester-oleic acid indicating that the phospholipid had the greater fractional turnover rate. The possible pathways for the synthesis of phospholipid and cholesterol ester by these cells and the significance of such synthesis in the pathogenesis of the atherosclerotic lesion is discussed.
Published Version
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