Abstract
This study aimed to investigate the antibacterial activity of three endodontic sealers, AH Plus, iRoot SP, and EndoSeal MTA, against four planktonic bacteria species. The antibacterial activity of the three endodontic sealers was assessed using a modified direct contact test. Bacteria suspension of Actinomycoses viscosus, Enterococcus faecalis, Staphylococcus aureus, and Streptococcus mutans were left in contact with the sealers that were pre-set or set for 1, 3, 7, and l4 days for an hour. Freshly mixed AH Plus and EndoSeal MTA were highly effective against all four tested bacteria as no surviving bacteria were recovered after treatment. Meanwhile, freshly mixed iRoot SP was not able to kill all bacteria, regardless of the species, demonstrating a weak antibacterial effect. After 24 h, AH Plus lost its antibacterial activity. EndoSeal MTA showed a strong and extended bactericidal effect against S. aureus and S. mutans for 3 days and A. viscosus for 7 days. In conclusion, fresh AH Plus and EndoSeal MTA exhibited a potent effect against all four bacteria species. EndoSeal MTA remained effective after setting when tested against A. viscosus, S. aureus, and S. mutans. Among all tested sealers, iRoot SP demonstrates the weakest antibacterial activity.
Highlights
Academic Editor: Edgar SchäferComplete elimination of microorganisms residing within the infected root canal system has always been the ultimate goal of endodontic treatment [1]
This study aimed to investigate the antibacterial activity of three endodontic sealers, including AH Plus, iRoot SP, and EndoSeal MTA, using a modified direct contact test (DCT)
It could be observed that there were no surviving bacteria for all four bacterial species when treated with freshly mixed AH Plus, indicating a strong and effective antibacterial activity
Summary
Complete elimination of microorganisms residing within the infected root canal system has always been the ultimate goal of endodontic treatment [1]. The successful rate of endodontic treatment is mainly composed of three main stages, including the removal of infected pulp tissues within the tooth [2–4], disinfection and shaping of the root canals, and lastly, the filling of the root canal chamber with inert materials [5–8]. Two main components are involved in the root canal filling phase, including a solid core material and a sealer [5]. The solid core material fills most of the space within the root canal while the endodontic sealer fills the remaining space, especially those within the accessory canals [10]. According to Komabayashi et al [12], there is a total of eight endodontic sealer types. Among these endodontic sealer types, tricalcium silicate-based endodontic sealers have gained popularity over the years due to their benefits, such as biocompatibility, lower microleakage, and antimicrobial activity
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