Abstract
The dissolution characteristics of beryllium (Be) metal particles and beryllium oxide (BeO) particles calcined at either 500 or 1000°C were studied in two solvents, simulated serum ultrafiltrate (SUF) and 0.1 N HCl. SUF was employed to model dissolution of particles deposited in lung, and HCl was used to examine dissolution kinetics. Although all of the particles were relatively insoluble, BeO calcined at 500°C had greater specific surface area and exhibited enhanced dissolution in both solvents compared to Be metal and BeO calcined at 1000°C. Analyses of solubility rate constants normalized for particulate specific surface area, however, showed that Be metal was the most soluble in 0.1 N HCl, followed by BeO calcined at 500°C and then BeO calcined at 1000°C. Dissolution of all the aerosols was slight in SUF and solubility rate constants in this medium were small for the three particle types. Data obtained in this study permit comparisons between the relative dissolution kinetics of Be metal and BeO particles and are of value in interpreting studies of the biokinetics and toxicity of inhaled beryllium in laboratory animals and in humans.
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