In vitro Antidiabetic and Anticancer Activity of Some Novel Diazenyl Benzene Sulphonamide Derivatives

Abstract

A series of novel 2-[(5-phenyl-1,3,4-thiadiazole-2-imino)substituted benzene]diazenyl benzene sulphonamide derivatives (VII)6-10 weresynthesized and FT-IR, 1H NMR, 13C NMR and GC-MS spectral data were used to investigate the structures of the synthesized sulphonamide derivatives. The antioxidant activity of 2-[(5-phenyl-1,3,4-thiadiazole-2-imino)substituted benzene]diazenyl benzene sulphonamide derivatives (VII)6-10 was done using DPPH technique. Compounds (VII)7 and (VII)9 displayed excellent antioxidant activity when compared to standard ascorbic acid. The in vitro antidiabetic activity on α-amylase and α-glucosidase studies indicated compound (VII)7 as promising inhibitor of α-amylase and α-glucosidase. The cytotoxic activity of the synthesized compound (VII)9 was tested against human colon (HCT-116), lung (A549), breast (MCF-7) cancer cell lines and fibroblast (L929) normal mouse lines. The results showed that compound (VII)9 has good cytotoxic activity.