Abstract
We investigate the chemical composition of aqueous and hydroethanolic extracts of Stryphnodendron adstringens by evaluating the total polyphenolic and tannin contents, antioxidant activity as well as marker compounds by UHPLC-MS. Through the in silico approach the molecular and pharmacokinetic parameters were predicted for the two major substances found in the extract, the pyrogallol (1) and chlorogenic acid (2). The antibacterial activity was verified by determining the MIC of the extracts on different bacterial strains. The inhibition zone diameter (ZD) of three different extracts of S. adstringens was studied, those with ZD>10mm proceeded to the determination of the MICs. The most active antimicrobial sample was S. adstringens ST3. The extracts of S. adstringens analyzed herein demonstrated not only high content of polyphenols and total tannins, but also antioxidant activity and activity against important bacterial pathogens like Streptococcus pneumoniae, Neisseria gonorrhoeae as well as against multiresistant bacteria such as MRSA (Methicillin-resistant Staphylococcus aureus) and Pseudomonas aeruginosa. The effects of S. adstringens extract on the phagocytosis and intracellular killing of Candida albicans and Candida. kefyr from two normal individuals were studied. We propose that the effect of S. adstringens on the neutrophils may be related to a possible mechanism for regulation functions in these cells.
Highlights
Plants are important sources of biologically active natural products, many of which constitute models for the synthesis of a large number of drugs
With a chemical structure that differs from that of antibiotics derived from microorganisms, plant antibiotics may govern the intermediary metabolism of pathogens by activating or blocking reactions and enzyme synthesis or even changing the structure of membranes (Ishida, et al, 2009)
In order to investigate the potential of plant species from the Brazilian Cerrado and encourage the use of these renewable resources, the present study aimed to investigate the antimicrobial action of Stryphnodendron adstringens (Mart.) Coville (S.adstringens), a medicinal plant rich in tannins
Summary
Plants are important sources of biologically active natural products, many of which constitute models for the synthesis of a large number of drugs. Research related to herbal remedies that can offer an alternative treatment of bacterial control has intensified (Pupo, et al, 2007). The study of these agents is essential as they are global, less toxic, but highly effective against bacterial resistance and able to combat new pathogens (Ostrosky, et al, 2008). In order to investigate the potential of plant species from the Brazilian Cerrado and encourage the use of these renewable resources, the present study aimed to investigate the antimicrobial action of Stryphnodendron adstringens (Mart.) Coville (S.adstringens), a medicinal plant rich in tannins. The quality of a herbal product starts with the evaluation of the botanical identity of the material, the evaluation of its purity, and characterization of the chemical constituents of the species, especially those involved in the therapeutic activity (Vendruscolo, et al, 2005)
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