In Silico Identification of the Antimastitis I Components in Allium cepa

Latha Ms

doi:10.19080/ctbeb.2018.13.555860

Abstract

Bovine mastitis is a pathogenic inflammation to the mammary gland of cattle results in huge reduction of milk production. Antibiotics are used for the treatment of mastitis. Limitted cfficacy of the antibiotic treatment is a threat to the diary industry. Farmers of South Kerala use the crude extract of Allium cepa for the treatment of mastitis and is found to be highly effective. Present study focus on the identification of the antimastitis components in Allium cepa which can perform efficient docking interaction with the target protein (PDB ID: 1JIL) of Staphalococus aureus bacteria using Schrodinger suit v 9.2. The phytochemicals, Myricetin, Quercetin-4'-glucoside and Quercetin-3-glucoside in Allium cepa are identified as the antimastitis components. The results of the study are helpful in developing novel drugs for the treatment of mastitis.

Highlights

Bovine mastitis is associated with the presence of infectious agents as bacteria, Bovine Herpes virus, non bacterial pathogens like mycoplasmas, fungi, yeast and chalmydia [1,2]
Various phytochemicals present in the plant are responsible for its therapeutic potential [4]. 20 phytochemicals in Allium cepa were selected for the docking study based on ADMET properties predicted by Qik prop option
Results and Discussion (Range of properties - Molecular weigh less than 500, Hydrogen bond donor 0-6, Hydrogen bond acceptor 2-20 and QP logP(o/w) -2 - 6.5), From the results obtained it has been understood that the phytochemicals Myricetin, Quercetin4’glucoside and Quercetin-3-glucoside are responsible for

Summary

Introduction

Bovine mastitis is associated with the presence of infectious agents as bacteria, Bovine Herpes virus, non bacterial pathogens like mycoplasmas, fungi, yeast and chalmydia [1,2]. Staphalococus aureus bacterial infections are most common. Transfer complex protein (PDB ID:1JIL) [3] is an excellent drug target in Staphalococus auerus. Inhibition of which results in bacterial cell lysis. Allium cepa is a biennial plant, a good source of nutrients. Various phytochemicals present in the plant are responsible for its therapeutic potential [4]. 20 phytochemicals in Allium cepa were selected for the docking study based on ADMET properties predicted by Qik prop option Various phytochemicals present in the plant are responsible for its therapeutic potential [4]. 20 phytochemicals in Allium cepa were selected for the docking study based on ADMET properties predicted by Qik prop option

Methodology

Results and Discussion

Conclusion