Abstract
Among the most prominent realizations of Morris J. Robins in the antiviral nucleoside chemistry are (i) the synthesis of 8-substituted (methyl-, amino-, bromo-, iodo) derivatives of acyclovir, (ii) xylotubercidin as an inhibitor of herpes simplex virus (HSV) infections, (iii) the anti-HIV activity of the 2’,3’-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and the 3’-azido- and 3’-fluoro derivatives thereof (AzddDAPR and FddDAPR, respectively), (iv) the potentiating effect of ribavirin on the anti-HIV activity of 2’,3’-dideoxyinosine (ddI) and ddDAPR, (v) S-adenosylhomocysteine hydrolase (SAH) inhibitors principally active against vaccinia virus (VV) and vesicular stomatitis virus (VSV), and (vi) furo[2,3-d]pyrimidinone derivatives active against varicella-zoster virus (VZV).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
