Abstract

Impulse conduction in human nerves is dependent on the electrical cable structure and voltage-dependent ion channels of the axonal membrane. Over recent decades, the development of specialized techniques such as patch clamping and site-directed mutagenesis has established the precise contribution of neuronal ion channel function to the processes of impulse conduction in myelinated nerves. With a better understanding of ion channel physiology and function, there arise important therapeutic implications in that the pharmacological manipulation of these channels and pumps may provide new therapeutic strategies for neurological disorders.

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