Abstract
Diabetes mellitus is common and rising in prevalence. Complications involving the nervous system, primarily polyneuropathy, can be detected in up to 50% of diabetic subjects. Diabetic polyneuropathy targets peripheral sensory neurons and leads to sensory loss and pain in the limbs. Diabetic subjects are also at risk of stroke, direct damage to the central nervous system, and complications of diabetic renal failure. Several mechanisms involved in the neurological complications of diabetes are outlined.
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