Abstract
Examined 140 women in the postmenopausal period. The phenomena of osteoporosis were revealed in all patients with a decrease of the T index of bone density by ultrasonic densitometry of the calcaneus. Decrease in serum 25-hydroxy-cholecalciferol levels. Increased markers of bone resorption of osteocalcin in the blood and disoxypyridinoline (DPID) in the urine. As a result of treatment, there was a normalization of the level of 25-hydroxycholecalciferol and a decrease оf osteocalcin in the blood and DPID in the urine in patients of the first group who received basic therapy, a combined preparation containing 1250 mg of calcium carbonate and 400 IU of vitamin D3 in one tablet. Patients of the second group, who received, in addition to basic therapy, alendronate, showed a normalization of the level of the metabolite of vitamin D3, as well as a decrease to normal levels of osteocalcin in the blood and DPID in the urine.
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