Abstract
AbstractNanomaterials have received growing attention in the treatment and diagnosis of neurological disorders because the low blood brain barrier permeability hinders the classical pharmacological approach. Metal ion chelators combined with nanoparticles prove effective in the treatment of neurodegeneration and are under extensive studies. Most chelating agents and metallodrugs compete with endogenous molecules for metal coordination, and do not reach the active site. Determining the competition between metallodrugs and endogenous molecules requires knowing the stability constants of formed metal complexes. In this study, for the first time, potentiometric titrations are used to determine metal complex formation constants, and to quantify ligand content in functionalized materials. This new potentiometric approach allows physico–chemical characterization of mesoporous functionalized materials and their metal adsorption capacity in water solution. The potentiometric results are compared with isotherm models obtained by spectroscopic measurements and yield rewarding data fitting. The potentiometric method described here can be extended to different types of nanostructured materials carrying surface ionizable groups.
Highlights
Nanomaterials have received growing attention in the treatment and diagnosis of and iron 340 × 10–6 m).[1,2] Nanomaterials neurological disorders because the low blood brain barrier permeability hinders the classical pharmacological approach
SBA-TETA joins versatility of mesoporous materials to load a large amount of cargo, environmental-friendly, and bioavailability, with TETA high efficiency in metal coordination
Potentiometry technique was used for the first time for ligand content quantification in the SBA-TETA material and for the determination of metal complex formation constants
Summary
Pluronic copolymer P123 (EO20PO70EO20) tetraethylorthosilicate, TEOS (≥99%); (3-chloropropyl)trimethoxysilane, CPTMS (≥97%); triethylenetetramine, TETA (≥97%); copper chloride dihydrate, CuCl2∙2H2O (≥99.0%), ZnCl2 (≥99.0%) anhydrous toluene (≥99.7%), dimethylformamide (DMF, ≥99.9%), acetone (≥99%), HCl (37%), NaCl, NaOH pellets were purchased from Sigma-Aldrich (Milano, Italy). Copper (1000 ± 2 ppm in HNO3 2% m/m) and zinc (1000 ± 2 ppm in HNO3 1% m/m) stock solutions were purchased from Fluka Analytical and Aldrich Chemical Company, respectively. Diethyl ether (99.8%), and ethanol (99.8%) were purchased from Honeywell
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