Editorial: Application of Omics Approaches to the Diagnosis of Genetic Neurological Disorders.

Andrea Legati,Edoardo Giacopuzzi,Monkol Lek,Marco Spinazzi

doi:10.3389/fneur.2021.712010

Abstract

Editorial: Application of Omics Approaches to the Diagnosis of Genetic Neurological Disorders.

Highlights

Specialty section: This article was submitted to Neurogenetics, a section of the journal Frontiers in Neurology
Given their rapidly decreasing costs, the increasing standardization of protocols, and the rapid turn-around time, these technologies are emerging as a powerful addition to standard diagnostic procedures. In this Research Topic four original papers highlight the potentialities of omics approaches in the diagnosis of genetic neurological disorders
Targeted re-sequencing using custom-made panels is highly efficient for the screening of up to hundreds potentially clinically relevant genes. This approach allows to perform genetic analysis in large cohorts of patients with affordable costs within a short timeframe, with the advantage of generating relatively low amount of data and easy to interpret results. In this Research Topic, to highlight the importance of targeted gene panels in the genetic diagnosis of neurological disorders, a study based on the genetic screening of more than 1,000 patients affected by autosomal optic atrophy have been included (Charif et al.)

Summary

Introduction

Specialty section: This article was submitted to Neurogenetics, a section of the journal Frontiers in Neurology. Editorial: Application of Omics Approaches to the Diagnosis of Genetic Neurological Disorders Application of Omics Approaches to the Diagnosis of Genetic Neurological Disorders

Results

Conclusion