Abstract
The aim of this study was to evaluate the effect of non-thermal plasma treatment on the biological properties of a natural hemostatic agent. The results show that plasma treatment can enhance the biodegradability property of the hemostatic agent by increasing the degradation rate of the specimen up to 94.26% within 7 days. Furthermore, the plasma-treated specimen also exhibited good biocompatibility based on the cell viability test of the fibroblast cells. The cell growth and cell proliferation on this sample were found to be helpful for the wound healing process. With appropriate degradable and biocompatible properties, this modified agent could be beneficial for better control over bleeding during surgery. Research on the physical and mechanical properties are on to develop novel hemostatic products to match the requirements as far as biomedical applications are concerned.
Highlights
Bleeding during a clinical procedure is a matter of concern
The small pores of CS sponge and its surface roughness are good for increased absorption via swelling, and it has the property of rapid blood absorption
This study investigated the effect of plasma treatment on the biological properties of a natural hemostatic agent
Summary
Bleeding during a clinical procedure is a matter of concern. Excessive hemorrhage is an important problem in surgery. Control of bleeding and rapid blood clotting are primary management tasks in an operation [1]. An effective hemostatic agent is an important equipment for this purpose. In the last few years, biomaterials have been employed to fabricate commercial use of natural hemostatic agents such as gelatin, rice starch, and oxidized cellulose, but some of them have not been costeffective or had some limitation for the application [2]. Chitosan (CS) has been successfully developed into a hemostatic agent with immediate blood absorption property. A previous study reported that CS was an effective material to fabricate the sponge hemostatic agent by using the freeze-drying technique. The small pores of CS sponge and its surface roughness are good for increased absorption via swelling, and it has the property of rapid blood absorption. CS was chosen as the raw material to produce the natural hemostatic agent for this investigation
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