Abstract
To evaluate the effectiveness and safety of combining 0.05% cyclosporine A (CsA) with high-potency steroids for treating severe dry eye disease (DED). This retrospective comparative case series included 93 patients treated with 0.05% CsA for severe DED. Among them, we included data from 54 eyes of 27 patients who received high-potency steroids in the study group and from 132 eyes of 66 patients who did not receive high-potency steroids in the control group. Data on demographic characteristics, comorbidities, medications and intraocular pressure (IOP) were recorded. The primary outcomes were changes in symptom and sign scores. The ocular surface disease index was used as the symptom score, whereas tear break-up time, Schirmer I test without anaesthesia, ocular surface staining scores and presence of meibomian gland dysfunction were considered as sign scores. Repeated one-way ANOVA and generalized linear mixed models were used to evaluate differences. In the control group, symptom scores decreased from 1 to 2months and from 2 to 3months after treatment (p=.002 and .049). In the high-potency steroid group, symptom scores improved during these intervals (p=.003 and .005). The sign score in the control group remained unchanged (all p>.05), while the high-potency steroid group exhibited progressive improvement in sign scores (all p<.05). The high-potency steroid group had more favourable symptom (p=.035) and sign (p<.001) scores than did the control group. However, multiple systemic diseases were associated with poor symptom (p=.025) and sign (p=.014) scores. The risks for glaucoma and cataract formation were similar between the two groups (all p>.05). Dual therapy combining high-potency steroids and 0.05% CsA significantly improved the signs and symptoms of severe DED compared with 0.05% CsA monotherapy, without severe complications.
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