Implications of Hydrogen Sulfide in Epigenetic Controlling in Neurodegenerative Diseases: A Narrative Review

Abstract

Previously we had we have reviewed various neurodegenerative diseases (NDD), inclusive of Alzheimer’s disease (AD), Parkinson’s disease (PD), as well as Huntington’s disease (HD), role of hydrogen sulfide (H2 S), in treatment of different cancers inclusive of breast cancer, glioma, hepatocellular carcinoma along with role of epigenetics in Diabetic Kidney Disease (DKD), as well as pregnancy. There by the objective of this review is provision of an exhaustive outline of the present research controlling epigenetic events correlated with NDD. Here we conducted a narrative review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms like neurodegenerative diseases (NDD); Alzheimer’s disease ; H2 S Parkinson’s disease; Huntington’s disease; hydrogen sulfide; Epigenetics; DNA methylation; Histone post-translational modifications; Histone protein acetylation; Histone methylation from 2000 till 2023 December till date. Emerging proof has initiated the unravelling of various facets by which H2 S impacts the epigenetic topography along with followed by the propagation of different NDD inclusive of AD, PD), as well as HD. H2 S possesses the capacity of modulating the crucial epigenetic machinery for instance DNA methylation, histone modifications along with noncoding RNAs influencing gene expression as well as cellular working germane to neuronal survival, neuroinflammation, as well as synaptic plasticity. Thus it is constructed how H2 S works in the form of an imperative actor amongst this close-knit network possessing the probability of opening innovative therapeutic arena. Although considerable work done, still lot of lacunae exist on the exact molecular modes plausible therapeutic repercussions of modulating the H2S quantities/its downstream targets. Finally isolation of future research directions having the objective of using the therapeutic capacity of H2 S in NDD.