Ovarian Low-Grade Papillary Serous Cystadenocarcinoma with Osseous Metaplasia- Case Report and Review of Literature

Abstract

Introduction: The stromal osseous metaplasia is extremely rare finding in serous cystadenocarcinoma of the ovary. Case report: A 45-year old female presented with pain in lower abdomen of about 2 months, breathlessness of 10days. On physical examination per abdomen, a large pelvic mass identified. She had pleural and pericardial effusion. Pericardiocentesis was done. Abdomen and pelvis ultrasound revealed a large heterogeneous right adnexal ovarian mass measuring 13.5 × 13.1 × 10.8cm, volume about 916 ml. It was well defined, oval, cystic, partially solid mass, the impression of ovarian neoplasm was given. There was no significant lymphadenopathy. The left ovary, uterus, cervix, fallopian tubes and rest of abdominal organs were normal. Serum CA 125 was 75.5 U/ml. She underwent total abdominal hysterectomy. On histopathological findings reported as right ovarian low-grade papillary serous cystadenocarcinoma with osseous metaplasia. Conclusion: The osseous metaplasia in ovarian serous cystadenocarcinoma is extremely rare.