Abstract
To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n=84), Ki67 index (n=79) and CD3 TIL (n=64) were prospectively evaluated. Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67≥15 was associated with shorter survival (p=0.018) but CD3 TIL was not (p=0.870). The highest graded prognostic assessment score was not associated with survival (p=0.648), however, those with low Ki67 and high score was associated with better outcome (p=0.007). High Ki67 index in brain metastasis carries a worse prognosis.
Published Version
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