Relationship between tumor infiltrating lymphocyte CD8+ stromal and intratumoral with grading, Estrogen Receptors (ER) and Progesterone Receptors (PR) expression in invasive breast carcinoma of no special type at Dr. Saiful Anwar General Hospital Malang

Abstract

Invasive breast carcinoma of no special type (IBC of NST) is a group of malignant epithelial neoplasms of the breast glands with the highest incidence of cancer in women. Tumor infiltrating lymphocytes (TIL) CD8+ is considered a group of T cells that play a role in the reactivity of specific immunity against cancer cells. TIL CD8+ group is a component that plays a role in specific adaptive immunity. TIL CD8+ infiltration in stromal tumor is related to a favorable prognosis and can predict the therapy outcome in patients. This study aims to determine the relationship between TIL CD8+ stromal and intratumoral with grading, ER and PR expression in the IBC of NST. The design of this study is analytical observational using 44 paraffin block samples in patients with IBC of NST at the Anatomical Pathology Department of Dr. Saiful Anwar Malang General Hospital by measuring TIL CD8+ expression on stromal and intratumoral, associated with grading and ER and PR expression. The results of this research showed that there is no significant relationship between histopathological grading with TIL (TIL CD8+ stromal p = 0.264, TIL CD8+ intratumoral p = 0.820), ER expression with TIL (TIL CD8+ stromal p = 0,297, TIL CD8+ intratumoral p = 0,145) and PR Expressions with TIL (TIL CD8+ stromal p = 0.240, TIL CD8+ intratumoral p = 0,003). In conclusion, there is no relationship between TIL CD8+ stromal and intratumoral with grading, expression of ER and PR in patients with IBC of NST.