Immunomodulatory Mechanism of Coronary Heart Disease and Related Therapeutic Applications and Prospects

Abstract

Coronary heart disease is a type of heart disease caused by stenosis or occlusion of the coronary artery lumen. The typical symptoms are chest pain, chest tightness, and aggravation after activity. It is divided into two categories, chronic coronary disease (CAD) and acute coronary syndrome (ACS). The pathological basis of CHD is coronary atherosclerosis, immune factors (cellular immunity, humoral immunity, autoimmunity, complement system, cytokines, adhesion molecules and apoptosis, etc.) are involved in the formation and development of atherosclerosis. So far, its pathogenesis has not been fully understood and there is no effective and specific drug treatment in clinic. This article is based on existing literature and research on the impact of immune regulation on coronary heart disease. To investigate the role of the immune system in the treatment of atherosclerosis, we analyzed the causes of atherosclerosis. Through literature search, this paper found the influence of infectious, autoimmune and chemical factors on atherosclerosis, and sought corresponding treatment methods for the cardiovascular and cerebrovascular injuries caused by these factors.