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Abstract
A unique morphological Sesamum radiatum oil/polyvinylpyrrolidone/gold polymeric bionanocomposite film was synthesized using the S. radiatum oil dispersed in a polymeric polyvinylpyrrolidone (PVP) matrix and decorated with gold nanoparticles (AuNPs). The chemical and physical characteristics as well as the thermal stability of the synthesized bionanocomposite film were investigated using various spectroscopic and microscopic techniques. The microscopic analysis confirmed well dispersed AuNPs in the PVP- S. radiatum oil matrix with particle size of 100 nm. Immunomodulatory and antiprotozoal potentials of the suggested bionanocomposite film were evaluated for lipopolysaccharide-induced BV-2 microglia and against L. amazonensis, L. mexicana promastigotes and T. cruzi epimastigotes, respectively. The results exerted outstanding reduction of inflammatory cytokines’ (IL-6 and TNFα) secretions after pretreatment of bionanocomposite. The bionanocomposite exhibited large inhibitory effects on certain cell signaling components that are related to the activation of expression of proinflammatory cytokines. Additionally, AuNPs and bionanocomposite exhibited excellent growth inhibition of L. mexicana and L. amazonensis promastigotes with IC50 (1.71 ± 1.49, 1.68 ± 0.75) and (1.12 ± 1.10, 1.42 ± 0.69), respectively. However, the nanomaterials showed moderate activity towards T. cruzi. All outcomes indicated promising immunomodulatory, antiprotozoal, and photocatalytic potentials for the synthesized S. radiatum oil/PVP/Au polymeric bionanocomposite.
Highlights
Recent advances in nanomaterials are due to the development of various engineered nanoparticles, noble metal nanoparticles such as (Silver, gold, platinum, etc.), which are considered as a distinctive group of nanomaterials with specific physical and chemical characteristics [1]
Considering the great medicinal benefits of sesame oil, AuNPs, and PVP, the present study suggests the synthesis of a polymeric sesame oil/PVP/Au bionanocomposite film and explores its biomedical potential, including immunomodulatory, antiprotozoal, and photocatalysis
Different pure solvents were used, including ethanol (99.0%), tetrahydrofuran (THF, 99.9%), N,N-dimethylformamide (DMF, 99.0%), dimethyl sulfoxide (DMSO, 99.9%), anhydrous chloroform (99.8%), Radioimmuno precipitation assay buffer (RIPA), lipopolysaccharide (LPS), cell counting kit-8 (CCK-8)Water-soluble tetrazolium salt (WST-8 reagent), 1% sodium3-dofo2-2 decyl sulphate, Quick RNA mini kit (Zymo Research, Irvine, CA, USA), High capacity cDNA Reverse Transcription Kit (Applied Biosystems, Thermo Fisher Scientific Inc., Waltham, MA, USA), and Liver infusion tryptose (LIT) medium. ity cDNA Reverse Transcription Kit (Applied Biosystems, Thermo Fisher Scientific Inc., 2W.2a. lBthotaamni,cMal AM,aUteSrAial), and Liver infusion tryptose (LIT) medium
Summary
Recent advances in nanomaterials are due to the development of various engineered nanoparticles, noble metal nanoparticles such as (Silver, gold, platinum, etc.), which are considered as a distinctive group of nanomaterials with specific physical and chemical characteristics [1]. Different pure solvents were used, including ethanol (99.0%), tetrahydrofuran (THF, 99.9%), N,Ndimethylformamide (DMF, 99.0%), dimethyl sulfoxide (DMSO, 99.9%), anhydrous chloroform (99.8%), Radioimmuno precipitation assay buffer (RIPA), lipopolysaccharide (LPS), cell counting kit-8 (CCK-8)Water-soluble tetrazolium salt (WST-8 reagent), 1% sodiumdodecyl sulphate, Quick RNA mini kit (Zymo Research, Irvine, CA, USA), High capac-. Different pure solvents were used, including ethanol (99.0%), tetrahydrofuran (THF, 99.9%), N,N-dimethylformamide (DMF, 99.0%), dimethyl sulfoxide (DMSO, 99.9%), anhydrous chloroform (99.8%), Radioimmuno precipitation assay buffer (RIPA), lipopolysaccharide (LPS), cell counting kit-8 (CCK-8)Water-soluble tetrazolium salt (WST-8 reagent), 1% sodium3-dofo decyl sulphate, Quick RNA mini kit (Zymo Research, Irvine, CA, USA), High capacity cDNA Reverse Transcription Kit (Applied Biosystems, Thermo Fisher Scientific Inc., Waltham, MA, USA), and Liver infusion tryptose (LIT) medium.
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