Abstract
The fibroblast surface antigen (SF antigen, fibronectin) a connective tissue component, is known to be present on the surface of fibroblasts and glial cells and to be shed to the surrounding medium. Anti-human fibronectin antibodies prepared in sheep reacted not only with human fibronectin but also with fibronectin in plasma and in fibroblasts of several other species including chicken. Sheep anti-chicken fibronectin similarly cross-reacted with some mammalian fibronectins. The cross-reactivity of these two fibronectins was destroyed by pronase, but not by periodate treatment. The cross-reaction between avian and human fibronectin suggests that fibronectin has remained highly conserved in evolution. This may be to do its functions as cell surface protein.
Published Version
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