Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients, treated or not with antiretroviral drugs

Abstract

Event Abstract Back to Event Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients, treated or not with antiretroviral drugs Karen I. Tasca1*, Caio C. Camargo1, Mariana Gatto1, Mônica B. Mendes1 and Lenice R. Souza1 1 Univ Estadual Paulista - UNESP, Tropical Disease, Brazil In HIV-infected even during antiretroviral therapy (ART) and absence of symptoms, the imbalance in immunological, hematological and biochemical factors can potentially contribute to progression to AIDS or other comorbidities. We aimed to analyze some of these parameters in 58 asymptomatic HIV-patients: ART-naïve (HIVn, n=18); virologic failure on ART (HIVf, n=18); on ART and complete viral suppression (HIVc, n=22). Quantification of viral load and CD4+ T cells were done by branched-DNA and flow cytometry, respectively. Sandwich immunosorbent assays were performed to quantify cytokines as IFN-g, TNF-a, IL-10 and IL-6. Other results were collected from medical records. Tukey-Kramer test and negative binomial and gamma distributions were calculated (p<0.05). Comparing three groups, we found the lowest levels of IL-10 in HIVc. The HIVf presented the lowest concentration of IFN-g and the highest levels of TNF-a and IL-6. To lymphocytes, mainly CD4+ T, HIVf presented lower counts than other groups. Triglycerides, high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) were higher in treat-patients (HIVc and HIVf) than HIVn. Total cholesterol was elevated in HIVc when was compared to HIVn, without difference to HIVf. An intriguing result was the higher aspartate-aminotransferase(AST) value found in HIVn than HIVc. When we checked the normal references ranges, the most common changes in the studied population were observed to neutrophils, total leukocytes, hematocrit, creatinine and metabolic exams. Thereby, therapeutic advances have contributed to the slower evolution to AIDS, however the laboratory changes observed in HIV+ deserve to be better understood in order to seek a greater -and better- longevity. Keywords: hiv/aids, Laboratorial changes, HIV-asymptomatics, antiretroviral drugs, Cytokines Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Host-pathogen interactions Citation: Tasca KI, Camargo CC, Gatto M, Mendes MB and Souza LR (2013). Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients, treated or not with antiretroviral drugs. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00552 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 02 May 2013; Published Online: 22 Aug 2013. * Correspondence: Miss. Karen I Tasca, Univ Estadual Paulista - UNESP, Tropical Disease, Botucatu, SP, Brazil, karenitasca@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Karen I Tasca Caio C Camargo Mariana Gatto Mônica B Mendes Lenice R Souza Google Karen I Tasca Caio C Camargo Mariana Gatto Mônica B Mendes Lenice R Souza Google Scholar Karen I Tasca Caio C Camargo Mariana Gatto Mônica B Mendes Lenice R Souza PubMed Karen I Tasca Caio C Camargo Mariana Gatto Mônica B Mendes Lenice R Souza Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.