Abstract
Immunologic Monitoring of Cellular Immune Responses in Cancer Vaccine Therapy
Highlights
Vaccine-induced immune responses against cancer depend on a balance between immune responses of various subsets of effector and suppressor T cells
Because tumor antigens are mostly self-antigens, this balance is shifted toward tolerance in cancer patients, so that generating effective antitumor responses requires breaking of tolerance
The suppressive compartment of the immune system includes a group of heterogeneous immune cells, including regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs)
Summary
Vaccine-induced immune responses against cancer depend on a balance between immune responses of various subsets of effector and suppressor T cells. Despite advances in the development of immune monitoring assays during the past decade, it has been difficult to establish significant correlations between vaccine-induced immune responses and clinical outcomes. These assays fail to define surrogate markers that could be used as predictors of clinical response and serve to advance vaccine development.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
