Abstract

A new protocol for the synthesis of chromeno[b]pyridine derivatives is described via a three-component reaction of 4-aminocoumarin, aromatic aldehydes and malononitrile catalyzed by TiO2 nanoparticles immobilized on carbon nanotubes (TiO2-CNTs) as an efficient heterogeneous catalyst under ultrasonic irradiation in water. The sustainable and economic benefits of the protocol are the high yields of products, short reaction time, simple work-up procedure, and use of a non-toxic and reusable catalyst.

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