Abstract
An environmentally benign method for the synthesis of octahydro-quinazolin-2,5-diones by the reaction of aromatic aldehydes, dimedone, and urea in the presence of SiO 2 -NaHSO 4 is reported. SiO 2 -NaHSO 4 acts as an efficient, mild, and recyclable heterogeneous catalyst to give excellent yields within a short reaction time in water at 60-80 °C. A rapid and environmentally benign method for the synthesis of octahydro-quinazolin-2,5-diones by the reaction of aromatic aldehydes, dimedone, and urea in the presence of SiO 2 -NaHSO 4 is reported. SiO 2 -NaHSO 4 acts as an efficient, mild, and recyclable heterogeneous catalyst to give excellent yield of the products within a short reaction time in water at 60-80 o C.
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