If Specimen Collection and Processing Guidelines Fall, Does Anyone Hear Them? Pre-Analytical Conundrums in Clinical Microbiology

Abstract

Provision of accurate and meaningful test results requires that all procedures, beginning with specimen procurement and ending with interpretation of final results, be performed according to best practices. Deviations may lead to under- or over-reporting of pathogens and incorrect assessment of an infectious process. Since we cannot assume that all procedures are performed according to protocols, relevant quality measures should be incorporated into routine practice. In this review, the most significant aspects of specimen collection, transport, and processing are discussed for the most important types of specimens. Microbiologists need to work closely with nurses and clinicians to maintain efficient practices and provide high-quality specimens.