Abstract
ABSTRACTBarbier and colleagues confirm a projection from the supramammillary nucleus to the claustrum using immunohistochemistry to validate the structural boundaries of the claustrum. This refines earlier conclusions made by Vertes and colleagues and highlights the importance of properly anatomically characterizing the claustrum for future structural and functional studies.
Highlights
The claustrum in the human brain is anatomically defined as the island of gray matter that lies between the external and extreme white matter capsules [1]
Pioneering anatomical work in rat performed by Vertes and colleagues identified a projection from the supramammillary nucleus (SUM) that terminates in the general area of the claustrum [8]
SUM neurons fire synchronously with hippocampal theta rhythms in rat and lesions of SUM in children are associated with disruptions in rapid eye movement (REM) sleep [9,10]
Summary
The claustrum in the human brain is anatomically defined as the island of gray matter that lies between the external and extreme white matter capsules [1]. Pioneering anatomical work in rat performed by Vertes and colleagues identified a projection from the supramammillary nucleus (SUM) that terminates in the general area of the claustrum [8]. Vertes and colleagues [8] injected an anterograde anatomical tracer into the SUM and observed SUM fibers in the general region occupied by claustrum, the endopiriform nucleus, and the insular cortex.
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