Abstract
ISOLATED mitochondria synthesize proteins1–3 and glycoproteins3–6 independently but the percentage of the mitochondrial protein synthesized by the mitochondrion itself probably does not exceed 5% (ref. 3), the rest being synthesized on cytoribo-somes3. Mitochondrial structural protein was thought to be the product of mitochondrial protein synthesis, but this fraction is heterogeneous and contains denatured ATPase7. Nevertheless, multi-macromolecular fragments of mitochondria have been implicated as products of autonomous mitochondrial synthesis8.
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