Abstract
An in-depth understanding into recent development and management of chronic hepatitis E virus (HEV) infection (CHE) is of interest as the underlying molecular mechanisms remain unexplored. The novel analysis conducted on the mRNA expression profile revealed a total of 69, 157 and 411 specific DEGs for mild, moderate and severe HEV, respectively. Interestingly, we found upregulated expression levels of 8 genes BATF2, OASL, IFI44L, IFIT3, RSAD2, IFIT1, RASGRP3 and IFI27, which shows their association with persistent HEV infection. Of these genes, 6 (OASL, IFI27, IFIT1, IFIT3, RSAD2 and IFI44L) made into the PPI network and were common at each stage of infection. This provides insights into these identified key genes and pathways which could be targeted to offer better interventions for CHE in future biological research.
Published Version
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