Abstract
Juvenile osteochondrosis, which can be complicated by a herniated disc, is a common disease in the pediatric population. Currently, this nosology is considered as one of the forms of manifestation of connective tissue dysplasia syndrome. A clinical study was conducted to identify dysplastic processes among 34 adolescents operated on for a herniated disc. Based on the characteristic phenotypic features, it was revealed that 15.36 % of the subjects had grade 1 connective tissue dysplasia, 74.47% — grade 2, and 10.17% — grade 3. The diagnosis was supplemented by a biochemical blood test for C-terminal telopeptides of type I collagen Beta-Cross Laps. In 18 patients (52,94%), the biochemical blood test exceeded the reference values, indicating consistency in the ongoing systemic catabolic reactions associated with the prevalent destruction of the collagen fibers of the tissues of the body.
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