Abstract
Post–acute withdrawal syndrome (PAWS) refers to a cluster of psychological and mood-related symptoms that can last for months to years after acute withdrawal from a substance and is a major contributing factor for relapse. PAWS symptoms exist for many individuals after withdrawal from alcohol, opioids, and benzodiazepines with underlying brain changes. Health care providers are in a prime position to identify and treat PAWS symptoms to decrease this risk of relapse. A synthesis of evidence on the state of the science of the limited but growing evidence on PAWS is explored. Patients experiencing PAWS need to be heard, supported, and appropriately treated by providers.
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