I2-promoted denitration strategy: one-pot three component synthesis of pyrrole-fused benzoxazines

Abstract

A facile and efficient protocol for the synthesis of pyrrole-fused benzoxazines has been developed via a novel molecular iodine-promoted denitration strategy, involving 2-amino phenols, acetylenic esters and β-nitrostyrene derivatives. This method offers the advantages of being nature friendly by avoiding use of metal catalyst and Brønsted acids, wide substrate scope, good yields, clean and simple methodology.