Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines

Abstract

An efficient synthesis of alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[2,1-c][1,4]benzoxazine-3-carboxylates and alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[1,2-a]quinoxaline-3-carboxylates is described. This involves a three-component reaction between o-aminophenols or o-phenylenediamine, acetylenic esters and β-nitrostyrene derivatives using p-toluene sulfonic acid as a catalyst.