Abstract
Prematurity refers to live births before 37 weeks of gestation and associated with infant morbidity/mortality. Activation of HIF during the final pregnancy phase is believed to play a critical role in the pathogenesis of premature birth and other pregnancy disorders. This study aimed to analyze the relationship between hypoxicstatus and the intensity of HIF-1α expression in a premature placenta.Stored biological materials premature placenta (paraffin blocks) was used in this study. Thirtyone samples of placental hypoxia (H) and 28 samples of premature placental non-hypoxia (N) as controls, were selected non-random consecutively. Subsequently, immunohistochemistry was performed to analyze HIF-1α expression. TheChi-square testwas used to analyze the data and a p-value <0.05 was considered statistically significant.Moderate to strong intensity of HIF-1α expressionwas observed in 58% of hypoxic placenta samples, whereas most of non-hypoxic placental samples(86%) did not expressed or expressed weaklyHIF-1α.There was a significant correlation between the intensity of HIF-1α expression and placental hypoxia (p <0.05) and Odds Ratio (OR) value was 8.31 with a 95% confidence interval (2.32-29.77). The conclusion shows that hypoxic status is associated with intensity of hypoxia inducible factor (HIF)-1α expression in a premature placenta.
Highlights
Prematurity is the birth of a live baby before 37 weeks' gestation, leading to inability to adapt to life outside the uterus due to its immature organ system
Hypoxia-inducible factor -1α is a subunit of hypoxia inducible factor (HIF)-1, regulating cellular homeostasis in response to hypoxic states.(Zaramellaet al., 2017) Hypoxia-inducible factor -1 was first discovered by Semenza, et al around 1991, in a study related to the erythropoietin gene (EPO).(Masoud and Li, 2015) In response to hypoxic states, the EPO gene is activated to transcribe in an effort to increase the production of red blood cells and oxygen-carrying capacity.(Vadlapatla, Vadlapudi and Mitra, 2013; Masoud and Li, 2015) This study found a DNA sequence that is important for the activation
This review reports the increasing of cell-free HIF-1α RNA expression in maternal plasma, which suffered from preeclampsia and IUGR
Summary
Prematurity is the birth of a live baby before 37 weeks' gestation, leading to inability to adapt to life outside the uterus due to its immature organ system. Premature birth events are associated with several risk factors, such as: history of previous preterm birth and abortion, anemia, high blood pressure, premature rupture of membranes, urinary tract infections, vaginal bleeding, twin pregnancy, oligohydramnios, preeclampsia, maternal age less than 20 years or more than 35 years old, less or no antenatal care, maternal smoking. June 2021 Page 1-11 habits, increased levels of catecholamines in the mother's urine, and less than a year of pregnancy interval. The etiology of prematurity is still debatable.(Ahumada-Barrios and Alvarado, 2016)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
