Body Mass Index and HbA1c Are Associated with Renal and Hepatic Function

Imam Nafiyana Saputra,Falah Faniyah,Yoga Mulia Pratama

doi:10.22219/sm.vol17.smumm1.15102

Abstract

Hypertension and diabetes may have implications for damage to other organs such as the kidneys and liver which are evaluated by serum creatinine and ALT, respectively. This study aims to delineate the association between body mass index and hbA1c with renal and hepatic function, respectively. This is a cross-sectional study involving 32 subjects. The research subjects consisted of diabetics and hypertension who were registered in the Muhammadiyah Primary Health Care, Kebanaran, Purwokerto. It was found that in diabetics, there were significant results between serum creatinine and HbA1c values (p <0.01, r = 0.855). Systolic blood pressure was correlated with body mass index (BMI) (p <0.01, r = 0.649). In patients with hypertension, serum creatinine was correlated with the length of time a person has hypertension (p <0.01, r = 0.475). Meanwhile, the ALT value was correlated with body mass index (p <0.05, r = 0.422) and waist circumference (p <0.001, r = 0.528). We found that a decreased HbA1c levels significantly reduces serum creatinine levels so it may also reduce kidney damage. A decrease in the value of BMI and waist circumference significantly reduces ALT enzyme levels which may have the potential for reducing liver damage.

Highlights

Non-communicable diseases have high mortality and morbidity in the world, especially hypertension (Mills, Stefanescu, & He, 2020) and diabetes mellitus (Ravindrarajah et al, 2020)
The diagnosis of diabetes mellitus was given if the participants had fasting blood sugar> 126 mg / dL, or blood sugar 2 hours post prandial> 200mg / dL, or HbA1c> 6.5%, according to the diagnosis given by the previous doctor
Patients consisted of 25 people with hypertension, 15 people with diabetes mellitus, and 8 people with hypertension and diabetes mellitus

Summary

Introduction

Non-communicable diseases have high mortality and morbidity in the world, especially hypertension (Mills, Stefanescu, & He, 2020) and diabetes mellitus (Ravindrarajah et al, 2020). Diabetes can have implications for damage to other organs such as the kidneys (Hamasaki & Morimitsu, 2020) and the liver (Teshome et al, 2019). Hypertension is closely related to decreased kidney function, especially in people with diabetes mellitus (Viazzi et al, 2020). Serum creatinine and ALT enzyme values are two markers that can describe renal (Ito, Matsue, & Minamino, 2020) and hepatic (Mangus et al, 2015) function, respectively. 72 Yoga Mulia P. et al./ SM Vol..

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