Hypothyroxinemia Effects in the Brain CytoarchiteHYPOTHYROXINEMIA EFFECTS IN THE BRAIN CYTOARCHITECTURE: STUDIES IN TRANSTHYRETIN-NULL MICE.

Abstract

Event Abstract Back to Event Hypothyroxinemia Effects in the Brain CytoarchiteHYPOTHYROXINEMIA EFFECTS IN THE BRAIN CYTOARCHITECTURE: STUDIES IN TRANSTHYRETIN-NULL MICE. Luis Martins1*, Joao Jose-Cerqueira1, Jose Miguel Pego1, Nuno Sousa1, Joana Almeida-Palha1 and Joao C. Sousa1 1 University of Minho, Life and Health Sciences Research Institute, Portugal Transthyretin (TTR) is the major rodent carrier of thyroid hormones and retinol. Both ligands are essential for the proper development of the central nervous system. In the absence of TTR, TTR-null adult mice showed altered behavior: decreased susceptibility in depression-like activity tests (forced swim test) and decreased- like anxiety performance in the open field test; moreover in the absence of TTR, 5-month-old mice display spatial reference memory impairment when compared to age-matched wild-type mice. One possibility for such altered behavior could be impairment in the development of the central nervous system. Even though adult TTR-null mice do not present signs of hypothyroidism, they are hypothyroxinemic (50% decrease in the total T4 levels). It has been described that when euthyroid hypothyroxinemia is chemically induced at certain periods throughout pregnancy, there is impaired neuronal migration in the hippocampus and sensomotory cortex. Moreover maternal hypothyroxinemia was shown to impair spatial learning and synaptic nature and function in the offspring. Because TTR-null mice are “naturally” euthyroid hypothyroxinemic, we analysed their hippocampus neuronal organization by evaluating the dendritic arborization and spine numbers and type in the hippocampus CA1 region at both 5-month and 18-month of age. Preliminary data indicate that 5-month- old TTR-null display a decrease in the length of the basal dendrites in neurons from the CA1 region when compared to wild-type mice. These results might correlate with the previously reported impairment in spatial learning memory in TTR-null mice. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Neurodegenerative Disorders Citation: Martins L, Jose-Cerqueira J, Miguel Pego J, Sousa N, Almeida-Palha J and Sousa JC (2009). Hypothyroxinemia Effects in the Brain CytoarchiteHYPOTHYROXINEMIA EFFECTS IN THE BRAIN CYTOARCHITECTURE: STUDIES IN TRANSTHYRETIN-NULL MICE.. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.084 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Aug 2009; Published Online: 10 Aug 2009. * Correspondence: Luis Martins, University of Minho, Life and Health Sciences Research Institute, Braga, Portugal, luismartins@ecsaude.uminho.pt Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Luis Martins Joao Jose-Cerqueira Jose Miguel Pego Nuno Sousa Joana Almeida-Palha Joao C Sousa Google Luis Martins Joao Jose-Cerqueira Jose Miguel Pego Nuno Sousa Joana Almeida-Palha Joao C Sousa Google Scholar Luis Martins Joao Jose-Cerqueira Jose Miguel Pego Nuno Sousa Joana Almeida-Palha Joao C Sousa PubMed Luis Martins Joao Jose-Cerqueira Jose Miguel Pego Nuno Sousa Joana Almeida-Palha Joao C Sousa Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.