The choroid plexus response to a sustained peripheral inflammatory stimulus

Abstract

Event Abstract Back to Event The choroid plexus response to a sustained peripheral inflammatory stimulus F. Marques1, Joana Palha1, Joao C. Sousa1*, G. Coppola1, D. Geschwind1, Nuno Sousa1 and Margarida Correia-Neves1 1 School of Health Sciences, University of Minho, Life and Health Sciences Research Institute, Portugal It is recognized that a chronic systemic inflammation might trigger alterations in the central nervous system (CNS). Several illnesses of the CNS, including multiple sclerosis and Alzheimer’s disease have an underlying chronic inflammatory component. Whether and how peripheral inflammation contributes in triggering the brain response in the course of such illnesses is far from understood. While most studies addressing communication between the periphery and the CNS focus on the blood-brain barrier (BBB), (formed by endothelial cells of the brain capillaries) increased attention has been paid to the involvement of the blood- cerebrospinal fluid (CSF) barrier (BCSFB) (formed by epithelial cells of the choroid plexus). In addition, the choroid plexus (CP) assumes an important role in the communication with the brain given its function as the major producer of the CSF. The composition of the CSF is altered in various CNS diseases, for which the CP secretome certainly contributes. In the present study we investigated the CP gene expression profile in response to a chronic inflammatory stimulus, induced by the intraperitoneal administration of lipopolysaccharide every two weeks for a period of three months and sacrificed 3 and 15 days after the last LPS injection. The data shows that the CP displays a sustained response to the chronic inflammatory stimulus by altering the expression of several genes even 15 days after the last injection. Despite the number of genes whose expression is found statistically altered, not many display a sustained fold change higher than five times and three times 3 and 15 days from last injection, respectively. Major altered pathways include those facilitating cells entry into the brain, and others that participate in the innate immune response to infection by microorganisms. Whether the final balance of the CP response is protective or deleterious for the CNS remains to be clarified and should be considered in the context of the brain response to inflammation. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Barriers of the Brain Citation: Marques F, Palha J, Sousa JC, Coppola G, Geschwind D, Sousa N and Correia-Neves M (2009). The choroid plexus response to a sustained peripheral inflammatory stimulus. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.032 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 Aug 2009; Published Online: 06 Aug 2009. * Correspondence: Joao C Sousa, School of Health Sciences, University of Minho, Life and Health Sciences Research Institute, Braga, Portugal, jcsousa@med.uminho.pt Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers F. Marques Joana Palha Joao C Sousa G. Coppola D. Geschwind Nuno Sousa Margarida Correia-Neves Google F. Marques Joana Palha Joao C Sousa G. Coppola D. Geschwind Nuno Sousa Margarida Correia-Neves Google Scholar F. Marques Joana Palha Joao C Sousa G. Coppola D. Geschwind Nuno Sousa Margarida Correia-Neves PubMed F. Marques Joana Palha Joao C Sousa G. Coppola D. Geschwind Nuno Sousa Margarida Correia-Neves Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.