Abstract
Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion. Hypoglycemic medications for type 2 DM have either proven inadequate or posed adverse effects; therefore, the Chinese herbal products are under investigation as an alternative treatment. In this study, a novel combination of fruiting body and mycelia powder of herbal Cordyceps militaris number 1 (CmNo1) was administered to evaluate their potential hypoglycemic effects in high-fat diet- (HFD-) induced type 2 DM in C57BL/6J mice. Body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), and blood biochemistry indexes were measured. Results indicated that CmNo1 lowered the blood glucose level by increasing insulin sensitivity, while no change in body weight was observed. Increased protein expression of IRS-1, pIRS-1, AKT, pAKT, and GLUT-4 in skeletal muscle and adipose tissue was found indicating restoration of insulin signaling. Additionally, PPAR-γ expression in adipose tissue restored the triglyceride and cholesterol levels. Finally, our results suggest that CmNo1 possesses strong hypoglycemic, anticholesterolemic, and antihypertriglyceridemic actions and is more economical alternate for DM treatment.
Highlights
Diabetes mellitus (DM) is one of the most common chronic diseases worldwide
Control mice were fed with normal chow (LabDiet 5010, 5.5% fat), while DM and CmNo1-DM group were fed with high-fat diet (HFD, 58Y1, DIO Rodent Purified Diet, TestDiet) with 61.6% fat (3.140 Kcal)
The Fasting Blood Glucose (FBG) value in DM mice was vigorously increased to 192.33 mg/dL while control showed a normoglycemic value of 99.67 mg/dL (Figure 1)
Summary
Diabetes mellitus (DM) is one of the most common chronic diseases worldwide. Type 2 DM, accounting for 95% of all cases, is a complex metabolic syndrome characterized by hyperglycemia resulting from either insulin resistance or inadequate insulin secretion. Type 2 DM is associated with comorbidities, encompassing obesity, heart disease, and stroke [1]. Along with genetic predisposition, are integral to the development of both diabetes and accompanying complications. The growing number of diagnoses of type 2 DM is correlated with increased consumption of low-cost, high-fat, and highcalorie diets [2]. Obesity is one of the leading causative factors of type 2 DM in both human and animal models
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