HYPERURICEMIA AND TELOMERE LENGTH IN SUBJECTS WITH NEW CASES OF HYPERTENSION ACCORDING TO THE 10-YEAR PROSPECTIVE STUDY

Abstract

Objective: To reveal the association of high level of serum uric acid and telomere length in 10-year prospective study using the data from Belarusian national representative survey. Design and method: In 2007/2008 a 10-year prospective analysis of 3500 randomized individuals living in a district of Vitebsk started (coverage of the survey was 97.9%). In 2012/2013 there was a second screening of this population (coverage of the survey was 84.3%) respectively. In 2017/2018 a 10-years prospective analysis included subjects with newly diagnosed hypertension in the second screening. Examination of these patients included standard questionnaires for detection of cardiovascular risk factors, measurements of blood pressure, blood chemistry, electrocardiography, echocardiography, ultrasound examination of brachiocephalic vessels, real-time PCR for the detection telomere length of peripheral blood lymphocytes. Results: We examined population of 2171 persons with normal blood pressure and 1257 persons with hypertension in 2007/2008. 286 new cases of hypertension developed in 5 years (14,4% of men and 12,2% of women). According to multifactorial regression analysis we revealed significant positive relationship between the frequency of new cases of hypertension and IV quartile of serum uric acid level (339–527 mmol/l) (df = 1; c2Wald = 5,1; p < 0,05) as well as other risk factors, adjusted for age and sex. Regression analysis of 170 randomized subjects showed that the IV quartile of uric acid level (339–527 mmol/l), determined at first screening, was associated with the I quartile of telomere length in 10 years in subjects with newly diagnosed hypertension adjusted for age and sex (df = 1; c2Wald = 4,9; p < 0,05). Conclusions: Level of serum uric acid > = 339 mmol/l was a risk factor for the development hypertension in 5 years in randomized urban population and detection of lower level of telomere length in 10 years in persons with new cases of hypertension.